inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´[Pubmed|22981860]

inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´, (p)ppGpp binds to the acive site of the enzyme and prevents the conversion of the apo-tetramer to the active dimer [Pubmed|31552824,22981860]

[PDB|1J7J] (from ''Salmonella typhimurium'', 51% identity, 73% similarity)

[PDB|6D9Q] (apo-protein) [pubmed|31552824]

[PDB|6D9R] (complex with the substrate PRPP) [pubmed|31552824]

[PDB|6D9S] (complex with ppGpp) [pubmed|31552824]

18179421, 22981860, 24001521, 6408059, 28189581

18179421, 22981860, 24001521, 6408059, 28189581, 31552824

K_M (PRPP): 166 µM [pubmed|31552824]

K_I (pppGpp): 1.7 µM [pubmed|31552824]